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Supplemental Figure S4 from VAX014 Activates Tumor-Intrinsic STING and RIG-I to Promote the Development of Antitumor Immunity

Year: 2026

Type: supplementary-materials

Abstract: Supplemental Figure S4. Activation of murine STING and human IFN-β promoter by VAX014 in the 293 Dual mSTING reporter cell line. A) SEAP enzymatic activity (mSTING reporter) and B) luciferase activity (huIFN-β transcriptional reporter) of cells treated with VAX-I or VAX014 rBMCs (MOI 70) or DMXAA (10 μM) for ∼20 hours. Histograms depict mean ± SEM.

DOI: 10.1158/1535-7163.32709583

Authors: Kinsey L. Nelson, Katherine A. Reil, Shingo Tsuji, Amanda M. Parikh, Mikella Robinson, Carrie D. House, Kathleen L. McGuire, Matthew J. Giacalone

Language: English

Topic: interferon and immune responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W7165000452

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