Work

Protein Phosphatase 5 Promotes SUMM2-Mediated Immunity by Facilitating Its Protein Accumulation

Year: 2026

Type: article

Abstract: Protein Phosphatase 5 (PP5) is an evolutionarily conserved serine/threonine phosphatase with a unique tetratricopeptide domain. It has been implicated in a wide range of cellular processes in mammals, but its function in plants is unknown. Here we uncovered that Arabidopsis PP5 is required for immunity mediated by the nucleotide-binding leucine-rich repeat immune receptor protein SUMM2. Loss-of-function mutations in PP5 suppress the autoimmune phenotypes caused by the activation of SUMM2 due to the disruption of the MEKK1-MKK1/MKK2-MPK4 kinase cascade. Further biochemical analysis revealed that SUMM2 interacts with Heat Shock Protein 90 and PP5, and SUMM2 level is reduced in pp5 knockout mutant plants, suggesting that PP5 functions as a co-chaperone to regulate the accumulation of SUMM2.

Source: Plants

DOI: 10.3390/plants15121875

Authors: Xingchuan Huang, Yanan Liu, Yuelin Zhang

Institutions: Neijiang Normal University, University of British Columbia, Sichuan University

Language: English

Topic: Plant-Microbe Interactions and Immunity

Subfield: Plant Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,258