Work

Supplemental Figure S22 from VAX014 Activates Tumor-Intrinsic STING and RIG-I to Promote the Development of Antitumor Immunity

Year: 2026

Type: supplementary-materials

Abstract: Supplemental Figure S22. Expression of type I IFN transcripts in tumors treated with VAX014 in vivo. A) Expression of IFN-β and several isoforms of IFN-α transcripts in excised i.d. MB49WT tumors treated with i.t. VAX014 at various treatment timepoints. Dashed line represents baseline normalized expression. B) Heatmap of IFN transcript log2 normalized expression at various treatment timepoints (n= 3). Violin plots show log2 normalized expression values as calculated by Rosalind and IFN transcript heatmap was generated using GraphPad Prism 10.

DOI: 10.1158/1535-7163.32709601

Authors: Kinsey L. Nelson, Katherine A. Reil, Shingo Tsuji, Amanda M. Parikh, Mikella Robinson, Carrie D. House, Kathleen L. McGuire, Matthew J. Giacalone

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W7165011935

Cites:

Cited by:

Related to: 3