Work

Mechanobiology of regulatory T cells: how cellular mechanics shape immune suppression

Year: 2026

Type: article

Abstract: Regulatory T cells (Tregs) suppress immune responses through multiple mechanisms, including contact-dependent removal of pMHCII and costimulatory ligands from antigen-presenting cells via trogocytosis and trans-endocytosis. These pathways require membrane deformation, receptor engagement, and vesicular trafficking. We propose that Treg efficiency in these processes is shaped by cellular mechanics—particularly membrane tension and actin organization—yielding a distinct biophysical signature for antigen-specific suppression.

Source: npj Biological Physics and Mechanics.

DOI: 10.1038/s44341-026-00039-5

Authors: Valeria I. Arteaga-Muñiz, Vishal Singh, Billur Akkaya, Cӧmert Kural

Institution: The Ohio State University

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,490