Work

Tumor–infiltrating CD8+Ki-67+ and CD8+LAG-3+ T cells are associated with improved patient survival in retroperitoneal dedifferentiated liposarcomas and leiomyosarcomas

Year: 2026

Type: article

Study design: Observational Study

Abstract: T cells were associated with inferior PFS. These findings highlight the clinical relevance of immune infiltration in retroperitoneal DDLPS and LMS. Moreover, they support the rationale for further exploration of the immune architecture for prognostic biomarkers and development of targeted immunotherapeutic strategies to improve the clinical outcomes of the patients.

Source: Experimental and Molecular Pathology

DOI: 10.1016/j.yexmp.2026.105057

Authors: Iva Benesova, Antonia Stammberger, Jan Balko, Jessica Pablik, Andrej Ozaniak, Luise Rupp, Robert Lischke, Jürgen Weitz, Jirina Bartunkova, Rebekka Wehner, Zuzana Ozaniak Strizova, Marc Schmitz

Institutions: Charles University, University Hospital in Motol, Fakultní nemocnice Motol a Homolka, Technische Universität Dresden, University Hospital Carl Gustav Carus, Helmholtz-Zentrum Dresden-Rossendorf, Nationales Centrum für Tumorerkrankungen Dresden, German Cancer Consortium (DKTK) Dresden, German Cancer Research Center

Language: English

Topic: Sarcoma Diagnosis and Treatment

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,640

Funders: Univerzita Karlova v Praze, Grantová Agentura, Univerzita Karlova, European Commission, Bundesministerium für Bildung und Forschung, Technische Universität Dresden, Ministerstvo Zdravotnictví Ceské Republiky, Fakultní nemocnice v Motole

Awards: G1870792943, G5373097964, G7193030452, G8494782663

OpenAlex ID: W7165017028

FWCI:

Cites: 69

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