Systems serology identifies FcR-related autoantibody signatures and functions for Sjögren’s syndrome
Year: 2026
Type: article
Study design: Observational Study
Abstract: Sjögren's Syndrome (SjS) has historically been associated with classical anti-Ro60/SSA, Ro52/SSA and La/SSB, however they are lacking in one third of the patients, which induces delays in diagnosis, and their disease-contributing role is debated. Here we have applied a SjS-tailored Systems Serology approach to a cohort of 58 SjS and 16 non-SjS sicca syndrome patients, and 40 healthy individuals, involving a multiplex assay measuring antibody isotype, subclass, Fc Receptor and complement engagement to 14 SjS-related autoantigens, an antibody-glycosylation profiling assay and a phagocytosis cell-based assay. Via a machine learning approach, we have identified unique autoantibody signatures, including classical and non-classical autoantigens-related features especially involving autoantigen-specific Fc Receptor binding, with apparent functional consequences. These findings provide interesting insights into the autoantibody responses in SjS, possibly paving the way for improved diagnostics, especially in difficult-to-diagnose patients (e.g., seronegative SjS and non-SjS sicca syndrome patients), and novel therapeutic options targeting autoantibody-specific Fc/Fc Receptor-related effector functions.
Source: EMBO Molecular Medicine
Authors: Martin Killian, Suzanne K Shoffner-Beck, Timon Damelang, Kevin John Selva, Kade E Wong, Samantha K Davis, Ebene R Haycroft, Bruce D Wines, P Mark Hogarth, Stephen J Kent, Lucile Grange, Baptiste Gramont, Flora Schein, Héloïse Munoz-Pons, Isabelle Guichard, Jean-Baptiste Gaultier, Anne-Emmanuelle Berger, Alice Haccourt, Blandine Chanut, Fabienne Jospin, Alexis Bocquet, Laurence Bouillet, Marc Ruivard, Yvan Jamilloux, Pascal Sève, Isabelle Durieu, Quitterie Reynaud, Jean-Christophe Lega, Amélie Servettaz, Hubert Marotte, Pascal Cathébras, Rémy Harlé, Edouard Ollier, Stéphane Paul, Kelly B Arnold, Amy W Chung
Institutions: Lyon 1 Université, Centre National de la Recherche Scientifique, Inserm, The University of Melbourne, Université de Lyon, Peter Doherty Institute, Centre Hospitalier Universitaire de Saint-Étienne, Centre International de Recherche en Infectiologie, Centre d'Investigation Clinique - Epidémiologie Clinique Saint-Etienne, Université Jean Monnet, University of Michigan, Burnet Institute, Monash University, The Alfred Hospital, Melbourne Sexual Health Centre, Université Jean Monnet, Institut polytechnique de Grenoble, Centre Hospitalier Universitaire de Grenoble, VetAgro Sup, Translational Innovation in Medicine and Complexity, Université Grenoble Alpes, Centre Hospitalier Universitaire de Clermont-Ferrand, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Hôpital Lyon Sud, Research on healthcare performance, Laboratoire de Biométrie et Biologie Evolutive, Centre Hospitalier Universitaire de Reims, Immuno-Régulation des Maladies Auto- immunes Inflammatoires et Cancer, Université de Reims Champagne-Ardenne, Mines Saint-Étienne, SAnté INgenierie BIOlogie Saint-Etienne
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $7,990
OpenAlex ID: W7165021741