Supplemental Figure S9 from VAX014 Activates Tumor-Intrinsic STING and RIG-I to Promote the Development of Antitumor Immunity
Year: 2026
Type: supplementary-materials
Abstract: Supplemental Figure S9. MB49 STING KO clones still respond to IFN-β by upregulating PD-L1 and MHC-I. A) Surface expression of IFNAR1 in MB49STING KO (STING KO) cells as analyzed by flow cytometry. MFI of unstained control was subtracted out and a secondary antibody control was included (n = 3). B) Surface expression of PD-L1 and MHC-I in MB49 STING KO cells ± IFNAR blockade co-incubated with VAX014-treated MB49 WT supernatants as determined by flow cytometry (n = 3). Histograms depict mean ± SEM of all combined experiments and dashed lines represent the baseline expression value of the corresponding untreated control. ns = not significant. #indicates which STING KO clone is represented in Figure 3.
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W7165022676