Figure 7 from Metastasis-Associated Wound Repair Promotes Reciprocal Lung Epithelium Activation and Breast Cancer Metastatic Outgrowth
Year: 2026
Type: other
Abstract: PDE4 isoform levels in lungs from patients with breast cancer (BC) with metastases. A, Lungs from normal (n = 28) and patients with BC with metastases (n = 17; Supplementary Table S1C for specimen demographics) were IHC-stained for PDE4 isoforms A–D. Shown are representative images from normal and metastasis-adjacent human lungs; scale bar, 20 μm, inset zoom 3x. B–D, Protein expression was scored by a clinical pathologist and presented as an IHC score. Isoform levels were scored in lung AT2 cells (B), the lung stroma, which included all metastasis-adjacent cells except AT2 cells (C), and metastases (D). Median and quartiles are indicated on each graph (nonparametric Kolmogorov–Smirnov tests for grouped data and nonparametric Kruskal–Wallis test for the intratumoral staining comparison). mBC, metastatic breast cancer.
Topic: Cancer Cells and Metastasis
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W7165026142
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