Year: 2026
Type: article
Abstract: Marine-derived microorganisms are a rich source of structurally diverse natural products with significant pharmaceutical potential. In this study, three new cyclic lipopeptides, amylimycins A–C (1–3), were isolated from a marine-derived Bacillus amyloliquefaciens strain. The chemical structures of these compounds were elucidated through comprehensive spectroscopic analyses and chiral derivatization using 1-fluoro-2,4-dinitrophenyl-5-alanine amide (FDAA). Amylimycins A–C (1–3) were identified as bacillomycin D analogs belonging to the iturin family, characterized by a cyclic heptapeptide core linked to a β-amino fatty acid moiety. Notably, these compounds featured uncommon branched β-amino fatty acid chains with varied chain lengths, representing a distinctive structural characteristic among bacillomycin D analogs. Amylimycins A–C (1–3) showed moderate antibacterial activity against the Gram-positive bacteria Bacillus subtilis and Staphylococcus epidermidis, while displaying weak to no activity against the Gram-negative strains Escherichia coli and Pseudomonas fluorescens.
Source: Marine Drugs
DOI: 10.3390/md24060218
Authors: Jaeyoun Lee, Seung Hyun Kim, Soohyun Um
Institutions: Yonsei University, Kookmin University
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,499
Awards: G2526494692, G4600372573, G5057612750
OpenAlex ID: W7165028009