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Patient-derived iPSC models suggest astrocytic involvement in DM1 neuropathology

Year: 2026

Type: article

Abstract: Myotonic dystrophy type 1 (DM1) is caused by a CTG-repeat expansion in the DMPKgene, producing toxic RNA that sequesters MBNL proteins and disrupts RNA splicing. In addition to muscular symptoms, DM1 causes cognitive impairments, suggesting central nervous system involvement. We model these effects using patient-derived iPSC-derived neurons (iNeurons) and astrocytes (hAstrocytes).

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.20728748

Authors: M. Simoes, Anton, Rahm, Lisa, Willemse, Marieke, Wansink, Derick, van Bokhoven, J.H.L.M. (Hans)

Institution: Radboud University Medical Center

Language: English

Topic: Genetic Neurodegenerative Diseases

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7165033675

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