Figure S2 from Dynamics of Immune Reconstitution and Impact on Outcomes across CAR-T Cell Products in Large B-cell Lymphoma
Year: 2026
Type: other
Abstract: Supplementary Figure 2. Boxplots with superimposed dot plots demonstrate immune subset distributions at clinically significant timepoints, including days 30, 100, 180, and 365 post-CAR-T. Axi-cel in highlighted in blue, liso-cel in green, and tisa-cel in red. Subsets shown are (A) CD4+CCR7-45RA+ effector cells, (B) CD4+CCR7+45RA+ naïve cells, (C) CD4+CCR7+45RA- CM cells, (D) CD8+CCR7+45RA+ naïve cells, (E) CD8+CCR7-45RA+ TEMRA cells, (F) CD8+CCR7-45RA- EM cells, and (G) CD8+CCR7+45RA- CM cells. Ranges of days 20 to 45, days 80 to 120, days 150 to 210, and days 300 to 400 were used to calculate the distributions for the boxplots for days 30, 100, 180, and 365, respectively. Note differences in y-axes across panels. Asterisks above each set of bar plots represent P-values as calculated by the Kruskal- Wallis test. * <0.05, ** <0.01, *** <0.001, and **** <0.0001, with absence of any asterisks representing P > 0.05.
Authors: Danny Luan, Susan DeWolf, Teng Fei, Sandeep Raj, Gunjan L. Shah, Caleb A. Lareau, Mohammad Alhomoud, Gilles Salles, Alfredo Rivas-Delgado, Kai Rejeski, Jae H. Park, Efrat Luttwak, Alejandro Luna de Abia, Magdalena Corona, Evangelos Ntrivalas, Giulio Cassanello, Marina Gomez-Llobell, Allison Parascondola, Michael Scordo, Katharine C. Hsu, M. Lia Palomba, Miguel-Angel Perales, Roni Shouval
Topic: CAR-T cell therapy research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W7165034811
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