Supplementary Figure S8 from Discovery of BBO-11818, a Potent and Selective Noncovalent Inhibitor of (ON) and (OFF) KRAS with Activity against Multiple Oncogenic Mutants
Year: 2026
Type: supplementary-materials
Abstract: Supplementary Figure S8 shows mean body weight and survival upon rechallenge in a KRASG12D syngeneic model treated with the combination of BBO-11818 and anti–PD-1 antibody. In addition, it shows mean body weight and mean tumor volume in KRASG12V and KRASG12D CDX models treated with BBO-11818 and BBO-10203 or BBO-11818 and cetuximab.
Authors: Carlos Stahlhut, Anna E. Maciag, Kyle A. Sullivan, Kanchan Singh, Nadege Gitego, Zuhui Zhang, Albert H. Chan, Alok K. Sharma, Patrick A. Alexander, Jin Shu, Yue Yang, Megan Rigby, Roger Ma, Saman Setoodeh, Brian P. Smith, Jun Pei, Dana Rabara, Erik K. Larsen, David M. Turner, Cathy Zhang, Cindy Feng, Siyu Feng, James P. Stice, Rui Xu, Ken Lin, Andrew G. Stephen, Felice C. Lightstone, Chunmei Ji, Keshi Wang, Dhirendra K. Simanshu, Dwight V. Nissley, Eli Wallace, Bin Wang, Kerstin W. Sinkevicius, Frank McCormick, Pedro J. Beltran
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W7165037373