Figure S2 from Synergistic Treatment of Prostate Cancer and Multiple Myeloma using CD46-Targeted Radioimmunotherapy Antibody–Drug Conjugates
Year: 2026
Type: other
Abstract: Figure S2: ZIP synergy analysis of the combination of [225Ac]Macropa-PEG4-YS5 and YS5-MMAE in DU145 and LNCaP cells. (A) ZIP synergy score heatmap for DU145 cells treated with matrix of YS5-MMAE and [225Ac]Macropa-PEG4-YS5 to study the synergistic effect. The heatmap indicates regions of synergistic interaction (red regions) and antagonistic interaction (green regions). (B) ZIP synergy score heatmap for C4-2B cells treated with varying dose of [225Ac]Macropa-PEG4-YS5 and YS5-MMAE, and their combinations. The heatmap demonstrates differential synergy and antagonism compared to DU145 cells, highlighting cell-line-specific responses to the combination therapy.
Authors: Anil P. Bidkar, Scott Bidlingmaier, Anju Wadhwa, Ellis Mayne, Athira Raveendran, Shubhankar Naik, Cheng Xue, Megha Basak, Kondapa Naidu Bobba, Bonell Patiño-Escobar, Nancy Greenland, Juan Antonio Camara Serrano, Veronica Steri, Jonathan Chou, Arun Wiita, Jiang He, David M. Wilson, Rahul Aggarwal, Henry F. VanBrocklin, Youngho Seo, Bin Liu, Robert R. Flavell
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W7165040556