Work

Whole body-MRI identifies widespread, low intensity inflammation in peripheral joints, and axial involvement in a third of patients with early, treatment-naïve, active PsA: data from the GOLMePsA clinical trial

Year: 2026

Type: article

Abstract: OBJECTIVES: To describe the prevalence and extent of whole body (WB)-MRI detected joint disease features and their response to therapy in patients with early, active PsA. METHODS: Newly diagnosed PsA patients (treatment-naïve), recruited in the GOLMePsA randomized trial (MTX plus golimumab and steroids, GOLMTX vs MTX plus steroids, PBOMTX), underwent a multi-joint MRI protocol (baseline; week 24 [primary outcome] and week 36). The validated WIPE (peripheral joints and entheses); HIMRISS, KIMRISS (hip and knee); HEMRIS (heel) and CANDEN and SPARCC (sacroiliac joints (SIJs), spine) scores were recorded. Exploratory estimates of difference or ratios (with CIs; 75-95%) between groups at weeks 24 and 36 were obtained using multiple binary logistic or quantile (median) regression. RESULTS: Overall, 93 paired scans from 31 participants (median symptom duration 10.5 months; IQR 4.2-18.3; absolute range 1.8-197.7; 68% polyarticular) were included. Baseline scores showed widespread low intensity inflammation in peripheral tissues (median MRI-WIPE score: 37-CI 19.0-55.0). SIJs and spine inflammation (SPARCC score ≥2) was seen in 25.8% (10/31) and 32.3% (10/31), respectively. Participants achieved median MRI-WIPE delta (the difference between time points) of -10 at week 24 and -7 at week 36 in the GOLMTX and -6 and -9 in PBOMTX arms, respectively. No differences between the treatment groups were observed. CONCLUSIONS: In this exploratory analysis, WB-MRI identified widespread although low intensity inflammation in peripheral joints and enthesis with improvements seen at 24 and 36 weeks and no meaningful differences between treatment arms. Axial abnormalities were seen in one third of patients at baseline. CLINICAL TRIAL REGISTRATION: Clinicaltrials.gov; NCT04108468.

Source: Lara D. Veeken

DOI: 10.1093/rheumatology/keag308