Supplemental Figure S14 from VAX014 Activates Tumor-Intrinsic STING and RIG-I to Promote the Development of Antitumor Immunity
Year: 2026
Type: supplementary-materials
Abstract: Supplemental Figure S14. MB49 RIG-I KO clones still respond to IFN-β by upregulating PD-L1 and MHC-I. A) Surface expression of IFNAR1 in MB49RIG-I KO (RIG-I KO) cells as analyzed by flow cytometry. MFI of unstained control was subtracted out and a secondary antibody control was included (n= 3). B) Surface expression of PD-L1 and MHC-I in MB49 RIG-I KO cells ± IFNAR blockade co-incubated with VAX014-treated MB49 WT supernatants as determined by flow cytometry (n= 3). Histograms depict mean ± SEM of all combined experiments and dashed lines represent the baseline expression value of the corresponding untreated control. ns = not significant. #indicates which RIG-I KO clone is represented in Figure 4.
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W7165054011