Work

Rational design of an environment-sensitive fluorescent probe for monitoring butyrylcholinesterase activity and its application in Alzheimer's disease

Year: 2026

Type: article

Abstract: imaging performance in both cellular and animal models, and successfully visualizes elevated BChE levels. These findings suggest that LY36 holds promise as a simple and effective visualization tool for AD diagnosis, progression monitoring, and therapeutic evaluation.

Source: RSC Medicinal Chemistry

DOI: 10.1039/d6md00363j

Authors: Ning Guo, Feng Wang, Yu Wang, Jiahao Du, Qingwen Zhang, Wenting Cao, Jiongtao Su, Fenqin Zhao, Junfeng Wang, Xiaobin Pang, Yuemin Zhou, Lin Yan

Institutions: Henan University, Henan University Huaihe Hospital and Huaihe Clinical Institute, Nanyang Medical College, Gordon Center for Medical Imaging, Massachusetts General Hospital, Second Affiliated Hospital of Zhengzhou University

Language: English

Topic: Cholinesterase and Neurodegenerative Diseases

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Natural Science Foundation of China

Award: G3428589725

OpenAlex ID: W7165059036

FWCI:

Cites: 31

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Related to: 10