Work

Senescence as a regulatory mechanism in skeletal muscle repair in young mice

Year: 2026

Type: article

Abstract: Senolytic treatment in young mice results in a transient delay in the repair kinetics of satellite cells, macrophages, and fibrosis without disrupting functional repair of skeletal muscle. Fibers associated with a p21+ nucleus were smaller in size than myofibers not associated with a p21+ nucleus, possibly signifying areas with delayed or incomplete repair or where greater senescence-associated signalling is needed to regulate nearby cell populations.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00154.2026

Authors: Amanda L. Johnson, Ryan T. Bevington, Gianni Parise

Institution: McMaster University

Language: English

Topic: Muscle Physiology and Disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Canadian Institutes of Health Research, Natural Sciences and Engineering Research Council of Canada