Work

Redox-sensitive GPCR signaling drives Gq-dependent Ca 2+ mobilization and cytokine production in human bronchial epithelial cells

Year: 2026

Type: article

Abstract: This study investigates how agricultural organic dust promotes airway inflammation. We show that organic dust extract rapidly induces ROS production along with a biphasic Ca 2+ response through a redox-sensitive, Gq-coupled G-protein coupled receptor (GPCR) network involving histamine, leukotrienes, and prostaglandins. This signaling cascade activates PKC isoforms that trigger production and secretion of inflammatory cytokines, linking oxidative stress to Ca 2+ -dependent inflammatory responses by the airway epithelium following organic dust exposure.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00223.2026

Authors: Jessica Lapiro, Yotesawee Srisomboon, Kayla Law, Scott M. O'Grady

Institution: University of Minnesota

Language: English

Topic: Asthma and respiratory diseases

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Minnesota Agricultural Experiment Station, National Institute of Allergy and Infectious Diseases