N’-(2-Hydroxy-4-methoxybenzylidene)-4- methylbenzohydrazide and its dinuclear nickel(II) and cadmium(II) complexes: Synthesis, crystal structures and urease inhibition
Year: 2026
Type: article
Abstract: Hydrazone compounds and their nickel(II) and cadmium(II) complexes have interesting biological activities. To explore new and efficient urease inhibitors, in this work an aroylhydrazone compound N'-(2-Hydroxy-4-methoxybenzylidene)-4-methylbenzohydrazide (HL) and two complexes [Ni2L2(CH3OH)2(OH2)2]Cl2·2CH3OH (1) and [Cd2L2(CH3COO)2] (2) have been prepared and characterized by elemental analysis, infrared and electronic spectroscopy, as well as single crystal X-ray determination. In addition, 1H and 13C NMR spectroscopy was used for HL. Both complexes are dinuclear compounds. The Ni atoms in complex 1 are in octahedral coordination, and the Cd atoms in complex 2 are in square pyramidal coordination. The Cl- in 1 acts as a counter anion, while the NO3- in 2 coordinates to the metal atoms with bidentate form. The urease inhibitory assay reveals that HL has weak activity, while complexes 1 and 2 have IC50 values of 18.2 ± 1.1 μmol L-1 and 0.38 ± 0.12 μmol L-1, respectively. Both complexes have higher activity than the standard drug acetohydroxamic acid (IC50 = 28.1 μmol L-1).
Source: Acta chimica slovenica
Authors: Chi Liu,, Liu-Xiu Chen, Zi-Fu Hu,, Wu Chen
Institution: Wuhan Textile University
Language: English
Subfield: Inorganic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W7165146495
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