Work

Electro‐Pyroptosis Immunotherapy of Cancer via Endoplasmic Reticulum‐Mitochondria Crosstalk Evoked by Ultrasound‐Activated Wireless Electrostimulation

Year: 2026

Type: article

Abstract: ABSTRACT Effectively inducing endoplasmic reticulum (ER) stress to initiate cell pyroptosis is promising to elevate cancer immunotherapy, as it avoids immune escape of tumor cells and insufficient differentiation of immune cells. However, it remains a major challenge due to the lack of effective ways to induce ER stress. Herein, we reported the conceptually new electro‐pyroptosis immunotherapy (EPI‐therapy) of cancer via ER‐mitochondria crosstalk by wireless electrostimulation ( w ES), enabled by ultrasound‐activatable ER‐targeted piezoelectric nanoplatform of FAL&BaTiO 3 @AuNPs that capable of generating a voltage nearly 400 mV for localized w ES to induce ER stress to trigger reactive oxygen species (ROS) generation. The developed EPI‐therapy overperforms the existing drug/chemical‐stimulated ones; it disrupts mitochondrial homeostasis and immunosuppressive microenvironment and activates a long‐term immune memory effect, triggering pyroptosis and immunogenic cell death (ICD) effect to boost the immunogenicity, and hence efficiently inhibit primary tumor growth while resist tumor recrudesce and lung metastasis, promising for future immunotherapy of cancer.

Source: Advanced Materials

DOI: 10.1002/adma.73770

Authors: Guohua Qi, Zutao Chen, Jianmei Li, Ziyi Fu, Zhanfeng Li, Yongdong Jin

Institutions: Shenzhen University, Yanshan University

Language: English

Topic: Nanoplatforms for cancer theranostics

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Natural Science Foundation of China