Supplementary Figure S2 from Single-Cell RNA-seq Analysis Reveals Distinct Tumor and Immunosuppressive T-Cell Phenotypes in Patients with CLL Treated with Ibrutinib
Year: 2026
Type: supplementary-materials
Abstract: Supplemental Figure S2. Patient characteristics and sample composition. A. The main body of the heatmap indicates the log10(number of cells) in each major cell cluster (partition) for each sample. Other sample characteristics are indicated in the legend. B. The absolute CD19+ B cell counts for each sample are shown according to timepoint and ibrutinib response. P values were calculated using a linear mixed-effects model with Timepoint as a fixed effect and a random intercept for patient to account for repeated measures. ****: p < 1 x 10-4, **: p < 0.01, *: p < 0.05. C. Time on ibrutinib treatment in days is shown for IBR and IBS patients. **: p < 0.01, Student t-test.
Authors: Shanmugapriya Thangavadivel, Jami Shaffer, Shrilekha Misra, Samon Benrashid, Britten K. Gordon, Alexander He, Wantong Li, Konur Oyman, Annika Chura, Shelby Cabrera, Altan Turkoglu, Tzung-Huei Lai, Kerry A. Rogers, Seema A. Bhat, John C. Byrd, James S. Blachly, Jennifer A. Woyach, Bradley W. Blaser
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W7165164499