Non-invasive evaluation of the respiratory system’s static compliance during assisted ventilation at various pressure support levels
Year: 2026
Type: article
Abstract: Spontaneous breathing activity during pressure support ventilation (PSV) is not beneficial for the assessment of static compliance (C st ). We designed a new scheme for determining C st during PSV and assessed its accuracy using a lung model. A Hamilton C3 ventilator was connected to an ASL5000 lung simulator that simulated different lung mechanics [system’s static compliance (C st ), 30 or 60 mL/cmH 2 O; airway resistance (R aw ), 5, 10, 15, or 20 cmH 2 O/(L·s)]. PSV and volume-controlled ventilation (VCV) underwent activation with tidal volume (V T ) values of 5, 7, and 10 ml/kg. Respiratory mechanics were obtained and corrected with virtual extrapolation by applying RC exp and relevant equations. The repeated change in pressure support (PS) level was set at ± 1 cmH 2 O. C st−PSV was determined from volume fluctuations resulting from PS level changes. The classic C st measurement was obtained with the end-inspiration approach during volume-controlled ventilation (C st−VCV ). Comparing the value of C st−VCV , similar values for C st−PSV were obtained at low PS level. By changing the PS level, the estimated C st−PSV resulted in a relatively high error of about 10–15%.The novel scheme provided reliable estimated results for C st during pressure support ventilation. Despite its limited accuracy affected by the spontaneous effort participation, this scheme may help in non-invasive, uninterrupted monitoring of C st .
Institutions: Shanghai Jiao Tong University, Shanghai Chest Hospital
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,890
Funder: Shanghai Jiao Tong University
OpenAlex ID: W7165192237