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Performance of Survival Prediction Tools in Patients With Gastrointestinal Stromal Tumors: A Systematic Review and Meta‐Analysis

Year: 2026
Type: review
Abstract: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. We conducted a systematic review and meta-analysis of studies that developed, validated, or updated clinical prognostic tools to predict survival in adults with primary GIST, identifying 47 eligible studies (38 development and 9 validation studies). Meta-analyses were performed to assess performance in external validation cohorts. The MSKCC nomogram was most frequently validated, with a pooled C-statistic of 0.78 for recurrence-free survival.
DOI: 10.1002/jso.70303
Authors: Alice Zhu, Chloe Wong, Neill K. J. Adhikari, Ka Yan Ip, Alyson Mahar, Amy T. Hsu, Julie Hallet, Natalie Coburn
Institutions: University of Toronto, Sunnybrook Health Science Centre, Sunnybrook Research Institute, Queen's University, University of Ottawa, Bruyère, Ottawa Hospital Research Institute, Odette Cancer Centre
Language: English
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $4,570
OpenAlex ID: W7165205256
FWCI:
Cites: 72
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