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Additional file 4 of Therapeutic targeting of RAGE/STAT3 signaling abrogates S100A7-driven breast tumorigenicity and immune suppression

Year: 2026
Type: other
Abstract: Supplemental Figure 4: RAGE/Stat3 inhibition suppresses S100A7-driven TNBC by modulating CD4⁺ T cells and assessing the impact of T-cell depletion. (A). The tumors harvested from S100A7-overexpression mice treated with vehicle control, RAGE, or Stat3 inhibitors, or their combination were analyzed for the different immune cells using multi-color flow cytometry. Effects of alone or combined Stat3 and RAGE inhibition on abundance or infiltration of IFNγ and TNFα positive CD4+ T cells. (B). Flow cytometry and bar plots depicting CD4⁺ and CD8⁺ T-cell depletion in Stat3/RAGE inhibitor–treated S100A7-overexpressing tumors. Data are mean±SEM. (n= 3 to 7). *p< 0.05; **p< 0.01; ***p< 0.001; ****p< 0.0001; ns: non-significant.
Source: Figshare
DOI: 10.6084/m9.figshare.32737884
Authors: Ghanta, Pratyusha, Verma, Ajeet K., Lin, Cho-Hao, Charan, Manish, Koshre, Ganesh R., Agarwal, Shashwat, Adorno, Jonathan, Garg, Ayush Arpit, Mukherjee, Tanisha, Miles, Wayne O., Song, Jonathan W., Mishra, Sanjay, Ganju, Ramesh K.
Language: English
Open Access status: green
OpenAlex ID: W7165360271
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