Additional file 5 of Therapeutic targeting of RAGE/STAT3 signaling abrogates S100A7-driven breast tumorigenicity and immune suppression
Year: 2026
Type: other
Abstract: Supplemental Figure 5: Expression of Serpin-E1 in breast tumor tissues and its correlation with S100A7 and immunosuppressive M2 macrophages. Expression of the SERPINE1 gene was analyzed in normal and breast tumor tissues, including metastatic samples, using (A). GENT2 (normal = 475 and tumor = 5574), (B). GEPIA (normal = 291 and tumor = 1085), (C). TNMplot (normal = 242, tumor = 7569 and metastatic = 82), and (D). UALCAN databases. Expression of the SERPINE1 gene was analyzed in (E). Normal and different lymph nodes (normal = 114, N0 = 516, N1 = 362, N2 = 120, and N3 = 77) and (F). hormonal status of breast cancer patients analyzed by mining UALCAN and METABRIC databases. Analysis of the correlation of SERPINE1 gene expression with (G). S100A7 gene expression in different breast cancer types (n = 10930) and (H). M2 macrophage infiltration in the basal subtype of breast cancer (n=191). ****p< 0.0001.
Source: Figshare
Institution: The Ohio State University
Language: English
Topic: S100 Proteins and Annexins
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7165372939