Additional file 6 of Therapeutic targeting of RAGE/STAT3 signaling abrogates S100A7-driven breast tumorigenicity and immune suppression
Year: 2026
Type: other
Abstract: Supplemental Figure 6: Stat3 inhibition reduces S100A7-induced Serpin-E1, and combined Stat3/RAGE inhibition with Serpin-E1 neutralization suppresses metastasis in S100A7-high TNBC, with minimal effect in S100A7-negative tumors. (A). Quantitation of Serpin-E1 in conditioned media of MDA-MB-231 scramble or vector control (231V) and S100A7 overexpressing MDA-MB-231 (S7OE) cell either treated with vehicle control (VC) or Stat3 inhibitor (IC50 value). Microscopic images show the H/E staining of (B). liver nodules, and (C). lung nodules in NSG mice injected with MDA-MB-231-S7OE cells and treated with Serpin-E1 nAb alone and in combination with Stat3 and RAGE inhibitors. (D-F). Representative harvested tumors, tumor volume, and weight in NSG mice injected with MDA-MB-231 cells that do not express S100A7 after the treatment of VC or Serpin-E1 nAb alone, RAGE/Stat3 inhibitors combination, and combination of Serpin-E1 nAb with RAGE/Stat3 inhibitors. Data are mean±SEM. (n= 3-4). ****p< 0.0001; ns: non-significant.
Source: Figshare
Institution: The Ohio State University
Language: English
Topic: S100 Proteins and Annexins
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7165380090