Evaluating the Association of Cancer-related Risk Factors With Multisystem Health: Insights Into Fertility, Cardiovascular, and Renal Indicators
Year: 2026
Type: article
Abstract: Cancer-related lifestyle and metabolic risk factors, including smoking, alcohol use, physical inactivity, and obesity, are widely recognized for their role in disease development. However, their association with multisystem health outcomes, particularly cardiovascular, renal, and reproductive indicators, remains less clearly characterized in general populations. This cross-sectional study utilized secondary data from the National Health and Nutrition Examination Survey (NHANES). Adult participants aged ≥20 years with complete demographic, clinical, laboratory, and questionnaire data were included (n = 5,588). Cancer-related risk factors were assessed, and outcomes included cardiovascular, renal, and fertility indicators. Statistical analyses included descriptive statistics, group comparisons, and multivariable logistic regression to estimate adjusted associations. A high prevalence of cancer-related risk factors was observed, including smoking, alcohol use, physical inactivity, and obesity. Multisystem abnormalities such as elevated blood pressure, dyslipidemia, and renal impairment were common. Obesity was consistently associated with cardiovascular outcomes and infertility. Smoking was associated with cardiovascular and renal indicators, while physical inactivity was associated with renal impairment. Alcohol use was not significantly associated with outcomes after adjustment. Cancer-related lifestyle and metabolic risk factors were associated with variations in cardiovascular, renal, and reproductive indicators within a general adult population. These findings highlight the presence of overlapping risk factors and multisystem health measures without extending beyond observed associations.
Source: Research
Author: Latha Kiran Krishna Rajendran
Language: English
Topic: Cancer Risks and Factors
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W7165381043