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Additional file 3 of Therapeutic targeting of RAGE/STAT3 signaling abrogates S100A7-driven breast tumorigenicity and immune suppression

Year: 2026
Type: other
Abstract: Supplemental Figure 3: RAGE/Stat3 inhibition reduces S100A7-driven TNBC by activating T-cell-mediated antitumor immunity. The tumors harvested from S100A7-overexpression mice treated with vehicle control, RAGE, or Stat3 inhibitors, or their combination, were analyzed for the different immune cells using multi-color flow cytometry. Effects of alone or combined Stat3 and RAGE inhibition on abundance or infiltration of (A). Granzyme, IFNγ, and TNFα positive CD8+ T cells, as well as (B). CD44+, CD69+, and granzyme-positive CD4+ T cells. Data are mean±SEM. (n= 3). *p< 0.05; **p< 0.01; ***p< 0.001; ****p< 0.0001; ns: non-significant.
Source: Figshare
DOI: 10.6084/m9.figshare.32737878
Authors: Ghanta, Pratyusha, Verma, Ajeet K., Lin, Cho-Hao, Charan, Manish, Koshre, Ganesh R., Agarwal, Shashwat, Adorno, Jonathan, Garg, Ayush Arpit, Mukherjee, Tanisha, Miles, Wayne O., Song, Jonathan W., Mishra, Sanjay, Ganju, Ramesh K.
Language: English
Open Access status: green
OpenAlex ID: W7165396037
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