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Additional file 2 of Therapeutic targeting of RAGE/STAT3 signaling abrogates S100A7-driven breast tumorigenicity and immune suppression

Year: 2026
Type: other
Abstract: Supplemental Figure 2: Impact of RAGE/Stat3 inhibition on S100A7-driven wound closure, in-vivo tumor cell proliferation, and total macrophage infiltration. (A). Effects of Stat3 and RAGE inhibition on wound closure abilities of (pA). S100A7 overexpressing MDA-MB-231 cells, and (B). S100A7-expressing MDA-MB-468 cells (C). Immunofluorescence analysis of cancer cell proliferation marker (Ki-67) in tumor sections of S100A7 overexpressing bi-transgenic mice injected with MVT1 cells and treated with Stat3 and RAGE inhibitors alone or in combination. (D). Flow cytometric analysis of CD11b+F/80+ tumor-associated macrophages (TAMs) in tumor tissues of S100A7 overexpressing bi-transgenic mice injected with MVT1 cells and treated with vehicle control (VC), Stat3, or RAGE inhibitors alone or in combination. (n= 3). ****p< 0.0001; ns: non-significant.
Source: Figshare
DOI: 10.6084/m9.figshare.32737872
Authors: Ghanta, Pratyusha, Verma, Ajeet K., Lin, Cho-Hao, Charan, Manish, Koshre, Ganesh R., Agarwal, Shashwat, Adorno, Jonathan, Garg, Ayush Arpit, Mukherjee, Tanisha, Miles, Wayne O., Song, Jonathan W., Mishra, Sanjay, Ganju, Ramesh K.
Language: English
Open Access status: green
OpenAlex ID: W7165395787
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