Work

Lineage plasticity driven by GATA6 loss fuels colorectal cancer metastasis

Year: 2026

Type: article

Source: Cell stem cell

DOI: 10.1016/j.stem.2026.05.013

Authors: Saori Goto, Vikram Deshpande, Ömer H. Yilmaz, Norihiro Goto

Institutions: Cornell University, Weill Cornell Medicine, Koch Institute for Integrative Cancer Research At MIT, Massachusetts Institute of Technology, Beth Israel Deaconess Medical Center, Harvard University, Broad Institute, Beth Israel Deaconess Hospital, Massachusetts General Hospital

Language: English

Topic: Cancer Cells and Metastasis

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute on Aging, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: Optimizing Gram-positive bacteria as a candidate for targeted anti-tumor therapy, Developing high-throughput genetic perturbation strategies for single cells in cancer organoids, PROSPECT - Stem cell models, Impact of fasting on intestinal stem cells and cancer, The lysosomal fasting response in intestinal stem cells and cancer, Effects of inflammaging on intestinal epithelial cells and aspirin chemoprevention., Cancer Center Support (Core) Grant, Immunometabolic regulation of CD8+ T cell mediated intestinal epithelial cell death in people with HIV (PWH), Understanding the role of the stromal cell niche in intestinal stem cell aging, Targeting a human gut bacterial genotoxin via engineered commensal bacteria, Development of a novel therapy targeting the tumor microenvironment in inflammatory breast cancer

OpenAlex ID: W7165523963

FWCI: 7.78

Cites: 83

Cited by: 3

Related to: 10