Get started
Work

Reviewer #3 (Public review): De novo design of protein binders that target DELE1 to inhibit the mitochondrial stress response

Year: 2026
Type: peer-review
Abstract: eLife AssessmentThis potentially valuable study describes the development of protein binders targeting DELE1, a protein involved in activating the integrated stress response when mitochondria are perturbed (the mitoISR pathway.The strategy appears to be successful, as several designed proteins were shown to bind DELE1, disrupt DELE1 oligomerization, and attenuate ISR activation.However, the demonstration of the utility of these inhibitory binders is incomplete, particularly given the limited biological outcomes examined in the current study, thus limiting the significance of the paper in its current form.
Source: eLife
DOI: 10.7554/elife.111905.1.sa0
Language: English
Subfield: Cell Biology
Open Access status: gold
Estimated APC paid: $2,500
Funders: Georgia Research Alliance, Case Western Reserve University, National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences, Argonne National Laboratory
Awards: G1633006425, G1800737955, Phase II SER-CAT Optimization: Acquisition of a next generation area detector, Acquisition of a High Precision Micro Diffractometer to Support NIH funded Research at SER-CAT, G6800544485, Computational Design of Protein Structures and Complexes, Acquition of a microdiffractometer for SER-CAT
OpenAlex ID: W7165664832
Cites:
Cited by:
Related to: 10