Work

Exploring gefitinib to enhance endocytosis of antibodies and nucleic acid aptamers targeting EGFR in glioblastoma

Year: 2026

Type: article

Abstract: Gefitinib induces massive EGFR endocytosis in glioblastoma, enhancing EGFR-targeting antibody and aptamer internalization, boosting antibody-drug conjugates and aptamer-siRNA conjugates in vitro .

Source: Nanoscale

DOI: 10.1039/d6nr00420b

Authors: Charlène D'Ancona, Elisabete Cruz Da Silva, Léa Denechere, Hélène Justiniano, Valérie Calco, Ludovic Richert, Romain Vauchelles, Dilara Sensoy, Candice Dussoulliez, Cendrine Seguin, Pascal Villa, François Daubeuf, Antoine Kichler, Sylvie Fournel, Halina Anton, Maxime Lehmann, Laurence Choulier

Institutions: Centre National de la Recherche Scientifique, Laboratoire de bioimagerie et pathologies, Université de Strasbourg, Plateforme de chimie biologique intégrative de Strasbourg, Inserm, Biomatériaux et Bioingénierie

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Agence Nationale de la Recherche, Ligue Contre le Cancer

Awards: Aptamer-mediated selective and modulable siRNA delivery, G8121121554

OpenAlex ID: W7165681256

FWCI: 1.278

Cites: 70

Cited by: 1

Related to: 10