In situ gelling gelatin/modified starch hydrogel containing curcumin-loaded niosomes for wound healing application
Year: 2026
Type: article
Abstract: Hydrogel dressings are one of the most appropriate agents for wound healing. Here, a novel, integrated hydrogel–based drug delivery system was developed for controlled curcumin (Cur) release for wound healing applications. To this purpose, a new hydrogel based on gelatin/ dialdehyde starch (DAS) was prepared using the Schiff-base reaction in the presence of curcumin (Cur)-loaded niosomes (HG/DAS/Nio/Cur). Cur was entrapped in Nio with an entrapment efficiency of 90%–95%. This system provides controlled release of Cur trapped in the hydrogel matrix and thus could improve its therapeutic ability. Dynamic light scattering indicated that Nio/Cur has particle sizes of 57.19 nm and a zeta potential of −8.21, respectively. The release rate from HG/DAS/Nio/Cur significantly increased, reaching 71% and 46% at pH = 5 and 7.4 after 72 h, respectively. The prepared hydrogels showed a high swelling ratio, and scanning electron microscopy revealed 3D porous structures (porosity around 87%–89%). Antimicrobial test showed E. coli inhibition effect but no S. aureus activity due to the thick peptidoglycan barrier. MTT assays confirmed >90% viability of human umbilical vein endothelial cells. These results suggest the potential of HG/DAS/Nio/Cur as an advanced wound dressing system.
Source: Biomedical Materials
Institutions: Tabriz University of Medical Sciences, University of Tabriz
Language: English
Topic: Wound Healing and Treatments
Subfield: Rehabilitation
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,325
OpenAlex ID: W7165767188