Year: 2026
Type: article
Abstract: flammatory markers such as C-reactive protein and erythrocyte sedimentation rate exhibit limited sensitivity and specificity [1].Although endoscopy remains the gold standard for IBD diagnosis [2], it is invasive, more costly, and less accessible compared with alternative methods.Consequently, there is a growing need for a simple, rapid, minimally invasive, and reliable diagnostic test.Fecal calprotectin has recently been recognized as a valuable diagnostic biomarker in this context.Calprotectin is a calcium-and zinc-binding protein predominantly localized in neutrophils and released during cell activation or death [3].Its presence in feces indicates neutrophil transmigration and infiltration into the intestinal mucosa.During GI tract inflammation, fecal calprotectin concentrations increase significantly.Assessing fecal calprotectin levels offers a less invasive alternative to colonoscopy, serving as a valuable screening tool that may reduce unnecessary endoscopic procedures [4].Moreover, several studies have demonstrated its utility in predicting disease recurrence [5].
Source: Laboratory Medicine Online
Authors: Banseok Kim, Young Ah Kim
Institution: National Health Insurance Service Ilsan Hospital
Language: English
Topic: Inflammatory Bowel Disease
Subfield: Genetics
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W7165780045
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