Work

Single-cell RNA sequencing: a powerful tool to study heterogeneity in papillary and anaplastic thyroid carcinoma

Year: 2026

Type: article

Abstract: Thyroid cancers are a complex ecosystem comprising cancer cells along with stromal and immune cells in the tumor microenvironment. In recent years, single-cell RNA sequencing has transformed our understanding of tumor heterogeneity, enabling in-depth analysis of thyroid cancer biology both within and across tumors. In this review, we explore the insights provided by this technology into the study of papillary and anaplastic thyroid carcinomas. We examine the phenotypic heterogeneity observed among cancer cells themselves, as well as the changes orchestrated by tumor cells in stromal and immune populations during cancer progression.

Source: European Thyroid Journal

DOI: 10.1530/etj-25-0141

Authors: Vicente Rodrigues Marczyk, Jennifer Rui Wang

Institution: The University of Texas MD Anderson Cancer Center

Language: English

Topic: Thyroid Cancer Diagnosis and Treatment

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7165790510