Work

The nuclear receptor ROR-alpha is a putative novel myogenic regulator of the cardiomyocyte transcriptome, including the alpha-1A adrenergic receptor

Year: 2026

Type: article

Abstract: The transcriptomic landscape of retinoic acid-related orphan nuclear receptor alpha (RORα) in the heart is defined for the first time. It includes key sarcomeric genes and other myogenic transcription factors. RORα is identified as the first bona fide transcriptional regulator of cardiac alpha-1A adrenergic receptor (α1A-AR) abundance, acting through direct binding to the Adra1a promoter to enhance its expression in cardiomyocytes, particularly under hypoxic stress. Cardiac α1A-ARs exhibit synchronous circadian oscillation with RORα, potentially revealing a previously unrecognized rhythmic regulatory axis.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00054.2026

Authors: Raghu Sundaresan Nagalingam, Ju Youn Beak, Richard D. Lutze, Wei Huang, Dhiren Akkina, Christina Kang, Anyue Zhao, Britney G. Alcira, Amir Aghajanian, Kevin E. Gerrish, Hong Soon Kang, Anton M. Jetten, Brian C. Jensen

Institutions: University of North Carolina at Chapel Hill, Virginia Tech, National Institute of Environmental Health Sciences, National Institutes of Health

Language: English

Topic: Nuclear Receptors and Signaling

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institutes of Health, Canadian Institutes of Health Research, National Heart, Lung, and Blood Institute, National Institute of Environmental Health Sciences

Awards: To examine the stress-mediated profibrotic and arrhythmic response in clinically relevant hypertrophic cardiomyopathy associated cardiac troponin-T (TNNT2) gene variants., Nuclear receptors: action, functions, and roles in disease, G3800359651, G972340078

OpenAlex ID: W7165857572

FWCI: 2.349

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Cited by: 1

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