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Correlation Between Total Leukocyte Count and Treatment Response in Breast Cancer Patients Under going Chemotherapy

Year: 2026

Type: preprint

Abstract: Breast cancer remains a leading cause of cancer-related mortality among women worldwide, and chemotherapy-induced myelosuppression frequently alters hematological parameters, including the total leukocyte count (TLC). This cross-sectional study was conducted at hospitals in Lahore over three months with 85 female breast cancer patients. TLC was measured and treatment response was classified as responder or non-responder. Results showed no statistically significant difference in TLC between responders and non-responders (Mann-Whitney U=764.0, p=0.223). ROC analysis yielded AUC=0.423. Baseline TLC alone was not a reliable predictor of chemotherapy response. TLC remains useful for routine toxicity monitoring but should not be used as a standalone prognostic marker.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.20844114

Authors: Adeel Ahmad, Hashmi, Khalid Mehmood, Miss.Rabia Butt, (Head Of Department), Miss. Iqra, (Lecturer), Miss. Atia, (Lecturer)

Language: English

Topic: Inflammatory Biomarkers in Disease Prognosis

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7165869427

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