Year: 2026
Type: article
Abstract: High Resolution Image Download MS PowerPoint Slide Metallosupramolecular assemblies are promising platforms for selective extraction, catalysis, and molecular recognition, yet their solution-phase synthesis often relies on complex self-assembly pathways that can be difficult to control. Here, using ion mobility mass spectrometry supported by density functional theory calculations, we introduce a gas-phase approach for directing topology in polymetallic complexes based on the encapsulation of coordination metal cations within a homometallic {Cr 8 } ring. Upon inclusion, the resulting host–guest complexes undergo collision-induced dissociation to produce distinct polymetallic fragments whose topologies, ring, host–guest complex or open chain, depend on the identity of the guest cation. This topology switching enables the targeted synthesis of new polymetallic rings, host–guest complexes and open chains in vacuo and provides insight into the stoichiometric and conformational preferences of such assemblies.
DOI: 10.1021/jacs.6c06300
Institutions: University of Manchester, Freie Universität Berlin, ETH Zurich
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
OpenAlex ID: W7165906126