Work

Pursuing the Red-Shift in Glycoporphyrins─A New Synthetic Approach toward Glycoconjugates from the meso -Tetraethynylporphyrin Scaffold

Year: 2026

Type: article

Abstract: Photodynamic therapy is a promising approach to anticancer treatment. For further development of this technique, new photosensitizers that better meet biological criteria are highly desired. Glycoporphyrins are considered more than favorable synthetic targets in this matter. This is due to their increased solubility in aqueous solutions and their targeting ability toward cancer cells. Herein, we report synthetic studies, and we propose an original Sonogashira-based strategy toward unique porphyrin-glycal conjugates. The proposed methodology allowed us to synthesize 5 new examples of photosensitizers in which the sugar unit influenced another crucial factorthe bathochromic shift of the photosensitizer's absorption profile. These structures were able to absorb wavelengths from the region of 740-780 nm. The studies present the development of a synthetic strategy toward water-soluble glycoporphyrins and the initial recognition of their singlet oxygen production ability.

Source: ACS Organic & Inorganic Au

DOI: 10.1021/acsorginorgau.6c00033

Authors: Jakub Mitrzak, Maciej Malinowski

Institution: Warsaw University of Technology

Language: English

Topic: Porphyrin and Phthalocyanine Chemistry

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,500