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Myocardial Perfusion and Fluorodeoxyglucose Uptake Patterns in Cardiac Sarcoidosis Stratified by Diagnostic Category and Systemic Involvement

Year: 2026

Type: article

Abstract: BACKGROUND: F-FDG PET/CT patterns in cardiac sarcoidosis (CS) across diagnostic subgroups are incompletely characterized. METHODS AND RESULTS: We analyzed 221 patients with definite CS (DCS), probable CS with active extracardiac sarcoidosis (PCS-A), or probable CS without extracardiac involvement (PCS-N). DCS exhibited more severe perfusion defects than PCS-A and PCS-N. FDG uptake was similar in DCS and PCS-A, but lower in PCS-N. Abnormalities predominated in the basal/mid-septum and apical cap. CONCLUSIONS: Distinct PET patterns characterize CS diagnostic categories and support current diagnostic criteria.

Source: Circulation Journal

DOI: 10.1253/circj.cj-26-0423

Authors: Daniel Sykora, Jen Davison, Gregorio Tersalvi, Mohamed Elwazir, Omar AbouEzzeddine, John Bois, John Giudicessi, Panithaya Chareonthaitawee, Leslie Cooper, Andrew Rosenbaum

Institutions: Mayo Clinic, Suez Canal University

Language: English

Topic: Sarcoidosis and Beryllium Toxicity Research

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7165926264

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