Work

In vitro fertilization-frozen embryo transfer in a patient with gonadotroph adenoma: Exacerbation of ovarian hyperstimulation by triptorelin: a case report

Year: 2026

Type: article

Abstract: BACKGROUND: Functional gonadotropic adenoma is a rare pituitary adenoma. Only a few cases have been reported. CASE PRESENTATION: Herein, we describe the case of a 30-year-old Chinese woman with functional gonadotroph adenomas (FGAs) with relative hyperprolactinemia and no obvious neurologic signs. Ovarian hyperstimulation due to a follicle-stimulating hormone (FSH)-secreting adenoma was observed after treatment with a gonadotropin-releasing hormone analogue (GnRH-a). The patient was successfully treated through pituitary adenomectomy and experienced a successful pregnancy after in vitro fertilization (IVF). CONCLUSION: Our report suggests that a patient showing ovarian hyperstimulation related to an FSH-secreting adenoma may present with high PRL and estradiol levels and indicates that transsphenoidal surgery should be the first choice for treatment.

Source: Journal of Medical Case Reports

DOI: 10.1186/s13256-026-06230-5

Authors: Feifei Lu, Manlin Xu, Xiaoyue Shen, Na Kong, Jingyu Liu, Yue Jiang

Institutions: Nanjing Drum Tower Hospital, Nanjing University

Language: English

Topic: Pituitary Gland Disorders and Treatments

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,890