Electrooxidative Iodination of Carbonyl Compounds: A Mild, Simple, and Scalable Access to α‐Iodocarbonyls
Year: 2026
Type: article
Abstract: A general method for α‐iodination of carbonyl compounds has been developed based on electrochemical generation of reactive electrophilic iodine species under mild reaction conditions. This work comprises quaternary ammonium salt as a stable and inexpensive iodine source. By employing electric current as a controllable and traceless alternative oxidant, our work eliminates the use of wasteful oxidants and hazardous reaction conditions. Thus, it demonstrates excellent tolerance toward oxidation‐sensitive substrates featuring aldehydes and heterocycles. Additionally, the reaction can be scaled up upon the introduction of a continuous flow setup.
Source: ChemElectroChem
DOI: 10.1002/celc.70264
Institution: Tallinn University of Technology
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,750
OpenAlex ID: W7165958713