Synchronization of the 12-h circatidal rhythm maintains the kidney through repeated cycles of warm reperfusion in the hibernating ground squirrel
Year: 2026
Type: article
Abstract: The hibernator kidney exhibits no damage after 10-22 cycles between prolonged cold exposure and rapid warm reperfusion occurring over several months. As found with kidney damage in other species, each rewarming activates an immediate early gene response. Unique to the hibernator, adaptive repair is completed within 12 h, facilitated by rapid activation of the universal "circatidal" rhythm unfolding on a seasonally primed background that assures minimal cell death, rapid cell division, and repair.
Source: Function
Institution: University of Colorado Anschutz
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,900
Funders: Center for Strategic Scientific Initiatives, National Cancer Institute, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, Eunice Kennedy Shriver National Institute of Child Health and Human Development
OpenAlex ID: W7166051819