Work

A tethered nitrenium strategy for functionalized morpholines

Year: 2026

Type: article

Abstract: We describe an effective strategy for the stereospecific synthesis of functional group-rich morpholines. Our reaction protocol benefits from the remarkable properties of tethered nitreniums and utilizes inexpensive, commercial hypervalent iodine oxidants. This technology is operationally simple and does not require the rigorous exclusion of air or ambient moisture for success.

Source: Tetrahedron

DOI: 10.1016/j.tet.2026.135440

Authors: Dnyaneshwar A. Gorve, Raju Silver, Steven P. Kelley, Shyam Sathyamoorthi

Institutions: University of Kansas, University of Missouri

Language: English

Topic: Oxidative Organic Chemistry Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $3,680

Funder: Foundation for the National Institutes of Health