Work

Persistent Placoid Maculopathy

Year: 2026

Type: article

Abstract: PURPOSE: To evaluate the long-term visual outcomes, recurrence, complication rate, and systemic associations of persistent placoid maculopathy. We also aimed to identify predictors of final visual acuity. METHODS: This study combined a retrospective multicenter case series from three tertiary referral centers with a systematic review of the literature. Inclusion criteria were bilateral placoid macular lesions with characteristic multimodal imaging findings and a minimum follow-up of 23 months. Visual acuity, systemic associations, complications, recurrence, and treatments were assessed. RESULTS: Twenty-three patients (46 eyes) were included, six patients from our centers and 17 patients from the literature. The median follow-up was 3.75 years. Severe visual loss (<20/100) at final follow-up was observed in one third of eyes. Choroidal neovascularization occurred in 65.2% of eyes and recurrence in 21.7%. Systemic cardiovascular comorbidities were common (87.5%), and two patients presented cerebral vasculitis. Systemic treatment was significantly associated with better final visual acuity ( P = 0.014). CONCLUSION: Persistent placoid maculopathy presents a high complication rate and poor visual prognosis. Systemic treatment was significantly associated with better final visual acuity in our study.

Source: Retina

DOI: 10.1097/iae.0000000000004914

Authors: Claire Seppey, Eirini Kaisari, Mickael Anjou, Chiara M. Eandi, Aude Ambresin, Antoine P. Brézin, Yan Guex-Crosier, Florence Hoogewoud

Institutions: Hôpital Ophtalmique Jules-Gonin, Fondation Asile des Aveugles, University of Lausanne, Hôpital Cochin, Université Paris Descartes, University of Turin

Language: English

Topic: Retinal Diseases and Treatments

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W7166099557

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