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Functioning, health-related quality of life and satisfaction of adults who required an amputation because of unrelenting complex regional pain syndrome type i; a scoping review using the International Classification of Functioning as a framework

Year: 2026

Type: article

Abstract: PURPOSE: Complex Regional Pain Syndrome Type I (CRPS-I) is a debilitating pain syndrome, for which amputation is sometimes considered a last resort. This scoping review explores effects of amputation on functioning, Health-Related Quality of Life (HRQoL) and satisfaction in adults with CRPS-I, using the International Classification of Functioning, Disability and Health (ICF) as a framework, and assesses differences between upper and lower limb amputations. MATERIALS AND METHODS: A final literature search was conducted December 2025 using PubMed, EMBASE, CINAHL, Web of Science and Cochrane databases. Studies were included if they reported on CRPS-I, amputation and outcomes related to functioning, HRQoL and/or satisfaction. Data was extracted and categorized according to ICF domains. RESULTS: Thirty-six studies were included. Improvements were reported in post-amputation pain, mobility, sleep, and mental functioning. Residual and phantom limb pain often persisted; CRPS recurrence was reported. Most HRQoL scores were significantly higher post-amputation compared to pre-amputation and non-amputated controls. Satisfaction rates were predominantly high post-amputation. No outcome differences were reported between upper and lower limb amputations. CONCLUSIONS: Amputation may improve aspects of functioning and HRQoL in selected individuals with therapy-resistant CRPS-I, with predominantly high satisfaction rates post-amputation. Stratified research and validated outcome measures are recommended for future studies.

Source: Disability and Rehabilitation

DOI: 10.1080/09638288.2026.2690018

Authors: P. N. Domerchie, M. J. Passchier, I. van Wijk, M. Lange, K. van Kammen, C. K. van der Sluis

Institutions: University Medical Center Groningen, University of Groningen, University Medical Center Utrecht, De Hoogstraat Revalidatie

Language: English

Topic: Pain Management and Treatment

Subfield: Anesthesiology and Pain Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: Rijksuniversiteit Groningen