Refractory Blue Rubber Bleb Nevus Syndrome in an Adult: Limitations of Endoscopic Therapy and Sirolimus
Year: 2026
Type: article
Study design: Case Report
Abstract: This case describes a 68-year-old man with recurrent gastrointestinal bleeding who was ultimately diagnosed with blue rubber bleb nevus syndrome with small-bowel predominance. Ongoing bleeding persisted despite multiple endoscopic interventions and medical therapy with sirolimus and octreotide, necessitating small-bowel resection. This case underscores the challenges in managing refractory gastrointestinal bleeding in adult late-onset blue rubber bleb nevus syndrome and highlights the potential role of early surgical intervention. The patient's sustained postoperative resolution of symptoms supports consideration of small-bowel resection in selected patients with small-bowel-predominant disease who fail endoscopic and medical therapies.
Source: ACG Case Reports Journal
Institutions: McGill University, McGill University Health Centre
Language: English
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7166197006