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Controlled Formation and Unusual Reactivity of Cyanohexatriyne (HC 7 N), a Synthetically Challenging Interstellar Cyanopolyyne

Year: 2026

Type: article

Abstract: ABSTRACT Cyanohexatriyne (HC 7 N), a highly unstable member of the interstellar cyanopolyyne family, has long resisted synthetic access. We report the first reproducible formation of HC 7 N at the milligram scale, enabled by a cobalt–alkyne masking strategy that circumvents the intrinsic instability of extended sp‐carbon chains bearing a terminal nitrile. This approach overcomes the limitations of classical C sp –C sp coupling methods and provides enough material for chemical investigation. The formed HC 7 N was characterized in solution and shown to undergo a rapid and stereoselective conjugate addition with diethylamine to the terminal C≡C triple bond.

Source: Chemistry - A European Journal

DOI: 10.1002/chem.71321

Authors: Léa Lefrançois, Mano Cremer, Thierry Roisnel, Jean‐Claude Guillemin, Yann Trolez

Institutions: Centre National de la Recherche Scientifique, Institut des Sciences Chimiques de Rennes, École Nationale Supérieure de Chimie de Rennes, Université de Rennes

Language: English

Topic: Catalytic Alkyne Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,640

OpenAlex ID: W7166314841

FWCI: 1.813

Cites: 34

Cited by: 1

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