Branched-chain and glucogenic amino acids predict brown fat recruitment and metabolic clearance in adults with overweight or obesity
Year: 2026
Type: article
Study design: Observational Study
Abstract: Elevated circulating branched-chain amino acids (BCAAs) are established biomarkers of metabolic dysfunction, but the regulatory role of human brown adipose tissue (BAT) remains unclear. We demonstrate that high baseline BCAA and glucogenic amino acid levels independently predict the capacity of BAT recruitment. Furthermore, successful BAT activation is associated with the systemic clearance of these metabolites. These findings suggest that BAT serves as a key regulator of amino acid homeostasis and represents a potential therapeutic target for addressing metabolic disorders in adults.
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Award: G1437944567
OpenAlex ID: W7166316199