SARS-CoV-2 infections in children undergoing anticancer therapy or hematopoietic stem cell transplantation: A multicenter nationwide study
Year: 2026
Type: article
Study design: Observational Study
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease 2019 (COVID-19) introduced an important public health threat in the world beginning in 2019. The aim of the study was to describe the clinical characteristics, treatment methods and outcomes of pediatric cancer patients and HSCT recipients who developed SARS-CoV-2 infection between 2020 and 2023 in Poland. During the study period among all pediatric oncological patients, 496 children (12.2%), i.e. 204 girls and 292 boys were at least one detected positive during anticancer therapy. Among HSCT recipients at least one episode of SARS-CoV-2 infection was diagnosed in 41 (6.0%; p < 0.001 oncology vs. transplant) patients, i.e. 10 girls, 31 boys including 39 (7.6%) after allo-HSCT and 2 (1.2%) after auto-HSCT (p = 0.001 allo vs. auto). SARS-CoV-2 infection has mild-moderate course in majority of pediatric cancer patients and transplant recipients, however, the presence of severe or critical illness is higher than in the general pediatric population. Interestingly, we observed less severe clinical courses of SARS-CoV-2 infection in the recent year than at the beginning of pandemic.
Source: Scientific Reports
Authors: Olga Zając-Spychała, S. Rutkowska, K. Derwich, K. Czyżewski, K. Jaremek, O. Grochowska, P. Zalas-Więcek, E. Bień, N. Irga-Jaworska, M. Salamonowicz-Bodzioch, J. Frączkiewicz, K. Kałwak, Ł. Hutnik, A. Szmydki-Baran, A. Minkowska, K. Pikora, P. Łaguna, K. Pawińska-Wąsikowska, S. Skoczeń, W. Balwierz, F. Pierlejewski, M. Nowak, M. Zdunek, W. Młynarski, W. Stolpa, K. Baranowska, A. Mizia-Malarz, M. Płonowski, M. Krawczuk-Rybak, O. Gryniewicz-Kwiatkowska, M. Łukszo, B. Dembowska-Bagińska, A. Królak, T. Ociepa, T. Urasiński, R. Tomaszewska, A. Książek, T. Szczepański, P. Wawryków, J. Peregud-Pogorzelski, T. Brzeski, K. Mycko, W. Badowska, J. Zawitkowska, A. Zaucha-Prażmo, K. Drabko, K. Smalisz, J. Goździk, A. Urbanek-Dądela, G. Karolczyk, S. Pająk, S. Krawczyk, K. Machnik, J. Styczyński
Institutions: Poznan University of Medical Sciences, Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, Gdańsk Medical University, University of Wrocław, Wroclaw Medical University, Medical University of Warsaw, Jagiellonian University, Medical University of Lodz, Medical University of Silesia, Medical University of Białystok, Children's Memorial Health Institute, Pomeranian Medical University, University of Warmia and Mazury in Olsztyn, Medical University of Lublin, Uniwersytecki Szpital Dziecięcy
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,690
OpenAlex ID: W7166324379
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